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The rate of use of various drugs differed between countries, from 32 for every 100,000 pregnancies in the Nordic countries to almost 300 for every 100,000 pregnancies in the U.S

doi: 10.1038/icb.2008.62 5 KorneteMMasonESPiccirilloCA

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The ESSENCE trial will provide valuable data on the maintenance of histological benefits over 240 weeks of continuous treatment, but long-term extension studies and off-treatment follow-up protocols are needed to characterize rebound kinetics

We hope to learn whether the health benefits observed in clinical trials will translate into real-world settings and diverse subpopulations. Originally developed to treat diabetes, GLP-1 receptor agonists help reduce food intake by mimicking a hormone that suppresses appetite
