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We believe that GLP-1 and BMS21 share the same binding site in the GLP-1R TM domain given their high sequence identity (7 identical of out 11 residues)

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GMA105 is a fusion protein that combines GLP-1 fragments with a humanized monoclonal antibody against GLP-1R, while GMA106 includes an antagonistic GIPR antibody fused with GLP-1 molecules, achieving dual receptor activation

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