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Such a diet promotes the shift from using carbohydrates as the body's primary fuel source to fats via a process called ketosis (Daley et al., 2025)

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Diabetic PPAR KO mice developed more severe DR while overexpression of PPAR in the retina of diabetic rats significantly alleviated diabetes-induced retinal vascular leakage and retinal inflammation, suggesting that fibrates could have direct effects on the retina to reduce DR (67)

10.1016/j.jacc.2019.11.046 [EL 4

Treatments are vehicle (V), cagrilintide (C, 2 nmol/kg), semaglutide (S, 2 nmol/kg), and calorie-restricted to match the weight of the CS rats (weight matched, WM)