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Coefficients for BMI change and percentage weight reduction remained largely consistent in sensitivity analyses limited to datapoints from in-clinic visits (Supplemental File 3)
Some providers prescribe both, using metformins insulin-sensitizing effects alongside semaglutides weight loss and appetite control
Certain drugs, particularly corticosteroids, atypical antipsychotics, and some anticonvulsants, can promote weight gain or worsen insulin resistance, counteracting tirzepatide's benefits
Saxenda commonly causes gastrointestinal side effects such as nausea, vomiting, and diarrhoea, particularly when initiating treatment or increasing the dose
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