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Low protein and calorie intake, electrolyte shifts like low sodium, and deficiencies in B12 or iron (low ferritin) can all cause: Fatigue Brain fog Depressed mood Before labeling Tirzepatide as the cause, I check: Daily protein intake, aiming for roughly 60 to 80 grams for many adults, depending on size and activity Hydration and salt intake should be considered if nausea or vomiting are present Labs: sodium, B12, ferritin, thyroid function, and glucose Who Might Be More At Risk For Mood Change On Tirzepatide

Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes

doi:10.1016/j.biopsych.2026.03.1002

The mice in the NC group and PCOS group were subcutaneously injected with the same volume of physiological saline

doi: 10.1007/s00125-012-2484-6 35 ChristensenMVedtofteLHolstJJVilsbllTKnopFK