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Another open-label, randomized phase III inferiority study looked at mean A1c reduction in type 2 diabetics not controlled on metformin when treated with semaglutide or tirzepatide and tirzepatide was again found non-inferior (and even superior) in reducing A1c

Third, although existing studies consistently demonstrate beneficial effects on hepatic steatosis and inflammation, the lack of head-to-head mechanistic and biomarker-based comparisons restricts the ability to distinguish between different GLP-1RAs or combination therapies in terms of their molecular pathways, immunemetabolic regulatory efficiency, and predictive biomarkers of therapeutic response

Use of these drugs peaks in middle age, then falls off a cliff right at 65

CONFLICT OF INTEREST STATEMENT CTP reports grants from Bayer and Novo Nordisk unrelated to the current study

We measure the odds ratio of developing pancreatitis between patients who have taken a large cumulative dose of GLP-1 agonist and those with a low cumulative dose of GLP-1 agonist