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Key points: Wegovy is a weight-loss injection and semaglutide is the active ingredient Semaglutide is injected weekly and mimics the fullness hormone GLP-1 to lower hunger and support weight loss

Drug Interactions Certain drugs may affect glucose metabolism, requiring insulin dose adjustment and close monitoring of blood glucose

Conclusions and Relevance In this cohort study, most patients with overweight or obesity discontinued GLP-1 RA therapy within 1 year, but those without type 2 diabetes had higher discontinuation rates and lower reinitiation rates

Heart Fail Rev 23:237253 Muiesan ML, Paini A, Agabiti RC (2017) Current pharmacological therapies in heart failure patients