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In short: the efficacy signal is genuinely strong and comes from real randomized trials, but Retatrutide remains investigational

Taking two injections within 48 to 72 hours can lead to serious side effects, including persistent vomiting, which could indicate pancreatitis

The findings were consistent after accounting for age, race, ethnicity, body mass index (BMI), breast density, and diabetes
doi: 10.1172/JCI116186 89 VilsbllTKrarupTMadsbadSHolstJ
While this effect contributes to the appetite-suppressing benefits of the medication, it can initially cause feelings of fullness, queasiness, and general digestive discomfort
