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For those impurities that are present at acceptable levels, an in silico risk assessment can identify immunogenic risk at an early stage in the development process, enabling the removal of higher risk impurities while also indicating additional in vitro assays (HLA binding and T cell assay) that would be most useful in further evaluating immunogenicity

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4.2 Anthropometric and glucometabolic parameters during the study period Body weight, BMI, and waist circumference were significantly lower after 3 months of therapy and up to T6 ( Figure 2 and Table 3 )

Together, these therapies highlight how treatment is evolving toward comprehensive metabolic care