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BV was supported by a CIHR postdoctoral fellowship
In more than 20,000 patient-years exposure to metformin in clinical trials, there were no reports of lactic acidosis

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This implies that DPP4is, characterized by their small molecular size (below 500 Da), can effectively hinder the enzyme's catalytic site, inhibiting its function, while preserving the molecule's capacity to act as a costimulatory factor without disruption
