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Some large analyses report lower rates of myocardial infarction, stroke, and all-cause mortality with tirzepatide compared with GLP-1 receptor agonists, including semaglutide ( Methodological limitations of comparative data Several methodological limitations complicate direct comparisons between these agents

2011 Jul;34(7):1041-3

But before you channel your inner rebel and ignore those dates, lets dive into what really happens when semaglutide expires and why playing it safe might be your smartest move

However, adverse effects on the cardiovascular and brain reward systems led to their discontinued use [878]

Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice