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When designing clinical trials to support new indications for use of FDA-approved GLP-1s, applicants should: Consider ways to leverage existing data (e.g., public data or previous FDA findings) to reduce the size, scope, timeline, and cost of development

GLP-1 receptor agonists are increasingly recognized for their potential to address the intersection between psychiatric disorders and obesity, a comorbidity associated with poorer outcomes and increased treatment complexity

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An agonist is a natural ligand or a substance mimics the action of natural ligands that initiates responses when it binds to a specific receptor

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