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Experimental design Effect of serotonin depletion on weight-loss impact of GLP-1R activation To assess the impact of serotonin depletion on the weight-loss effect of GLP-1R activation, serotonin depleted rats were injected with EX4 and their body weight was followed for five consecutive days of central EX4 injections

Clinical trials have reported dose-dependent increases in heart rate, which peaked at 24 weeks and then declined after that point

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