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Additionally, if you develop a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2, tirzepatide is contraindicated

This happens when the signal that leptin sends to the brain doesnt work properly, a condition which is known as leptin resistance

Our goal is long-term success
Researchers who have plateaued on dual agonists are exploring whether the switch from tirzepatide to retatrutide provides another level of receptor novelty and metabolic activation

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