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dpp-4 inhibitors vs. glp-1 agonist Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Working mechanisms of GLP-1, GLP-1

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doi: 10.2337/dci17-0057 224 HeineRJVan GaalLFJohnsDMihmMJWidelMHBrodowsRGet al

dpp-4 inhibitors vs. glp-1 agonist Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Working mechanisms of GLP-1, GLP-1

Therefore, considering the direct role of GIP and GLP-1 in adipose tissue, this effect on adipose tissue may also be beneficial in NAFLD

dpp-4 inhibitors vs. glp-1 agonist Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Working mechanisms of GLP-1, GLP-1

It means we do not have the quality of evidence needed to make confident claims about efficacy

dpp-4 inhibitors vs. glp-1 agonist Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Working mechanisms of GLP-1, GLP-1

35 SGLT-1 is primarily responsible for glucose absorption in the gastrointestinal tract and only accounts for approximately 10% of glucose reabsorption in the kidney

dpp-4 inhibitors vs. glp-1 agonist Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Working mechanisms of GLP-1, GLP-1

15 they also reduce body weight by activating GLP1R in the central nervous system and suppressing appetite

dpp-4 inhibitors vs. glp-1 agonist Insights into the Roles of GLP-1, DPP-4, and SGLT2 at the Crossroads of Cardiovascular, Renal, and Metabolic Pathophysiology Working mechanisms of GLP-1, GLP-1

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