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Some retrospective data shows patients on antidepressants lose slightly less weight overall on GLP-1 agonists, but this likely reflects the underlying depression rather than a pharmacological conflict

Because this is an off-label use, insurance may not cover the weekly injections, which can be costly

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The risk of weight regain needs to be addressed, perhaps through individualized dose-tapering strategies, given the increasing popularity of these agents for weight loss and the high discontinuation rates

This elevation reflects increased creatine metabolism rather than impaired kidney function