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ECL3 appears to play a role in ligand and/or ECD recognition in GCGR (Koth et al., 2012)
On top of that, when you're eating less common in the early months you get less water from food

Glucagon Activation Increased energy expenditure, hepatic fat oxidation, and basal metabolic rate, expanding the therapeutic mechanism beyond appetite alone

In order to see results, you must adjust your diet and activity levels
