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Saxenda, the second to be approved, only achieved middling weight-management results for a large share of those who took it, and physicians were reticent to prescribe weight-loss medications after the disastrous effects of drugs such as fen-phen were revealed in the late 90s

doi: 10.1016/j.redox.2023.102727

2017;66(suppl 1):1179-P

In in-vitro and preclinical studies, it demonstrates notable effects on weight and glycemic indices, prompting further investigation into triple agonists that target GLP1, GIP, and glucagon receptors

Four leading organizations in lifestyle medicine, obesity medicine, and nutrition-the American College of Lifestyle Medicine (ACLM), the American Society for Nutrition (ASN), the Obesity Medicine Association (OMA), and The Obesity Society (TOS)-have jointly released a clinical advisory titled "Nutritional Priorities to Support GLP-1 Therapy for Obesity." Published across four peer-reviewed journals, this consensus-based guidance reflects an interdisciplinary collaboration to help clinicians support patients receiving GLP-1 receptor agonists for obesity care with evidence-based nutritional and behavioral strategies