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Larger and longer studies in broader populations are needed to fully understand the safety and efficacy in people with alcohol use disorder, but these initial findings are promising. About this study: In addition to Hendershot and Klein, other authors of the study are Michael Bremmer, Michael Paladino, Georgios Kostantinis, Thomas Gilmore, Neil Sullivan, Amanda Tow and Robyn Jordan, all of University of North Carolina at Chapel Hill

doi:10.1016/j.mayocpiqo.2023.11.004

The receptor is in an inactive conformation with compounds that restrict movement of the intracellular tip of helix VI, a movement that is generally associated with activation mechanisms in class A GPCRs

Set your deficit targets, ensuring you stay in a calorie zone that supports healthy weight loss

The metabolic cost of the medication outweighs any theoretical benefit from weight loss for competitive runners