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Tirzepatide, a dual agonist of GLP-1 and GIP receptors, is the most advanced compound in its class: in the SUMMIT trial, among patients with HFpEF and obesity or type 2 diabetes, it lowered the risk of HF-related adverse events and cardiovascular death [19]

Importantly, GLP-1RA significantly reduced the frequency and duration of seizures in the mouse model of epilepsy
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