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In the landmark STEP-1 clinical trial, participants receiving semaglutide 2.4 mg once weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% with placebo

Thinking about life after GLP-1s

This makes the comparison of semaglutide vs bariatric surgery weight loss a critical factor for those with a high BMI or severe comorbidities

The FDA has raised specific concerns about compounded semaglutide products, including reports of adverse events tied to dosing errors and concerns about the use of salt forms not present in FDA-approved formulations

This mechanism explains why some people on retatrutide never feel truly hungry but also never feel truly energized