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Also, be aware that GLP-1s can cause side effects like nausea, vomiting, diarrhea, constipation, and heartburn, says Adrienne Youdim, MD, a weight loss specialist in Beverly Hills, California

It does not have long-term safety data

Plus, says Vash, when you go to the bathroom, the medication causes an oily discharge. (Thats the fat your body isnt absorbing.) And, he says, orlistat results in an average 6% weight loss, which is much lower than other weight-loss medications

It must be taken on an empty stomach with minimal water (no more than 4 ounces), which creates a unique hydration challenge

Like with most medications, there are risks of more serious side effects