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doi: 10.1111/dom.12593 [DOI] [PubMed] [Google Scholar] 28

This triggers several beneficial effects: Enhanced insulin secretion from the pancreas when blood glucose levels are elevated Reduced glucagon release , which prevents the liver from producing excess glucose Slowed gastric emptying , meaning food moves more slowly from the stomach into the intestines Increased satiety signals to the brain, reducing appetite and food intake These combined mechanisms help lower blood glucose levels in people with type 2 diabetes and promote weight loss in those with obesity

Mechanism is incompletely understood but may be related to GLP-1 associated vasodilation hypoperfusion of optic nerve edema and infarction