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13 Additionally, a cohort study from the United States indicated that the use of GLP-1 RA was significantly associated with a higher risk of arthritis compared to both non-users and users of DPP-4i
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Other clinically relevant GI complications include cholelithiasis, which occurred about 50 % more often, and gastroesophageal reflux disease (GERD), which occurred roughly twice as often, in patients receiving GLP-1 therapies compared with placebo [33]
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