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Gastrointestinal side effects , particularly diarrhoea and vomiting, are common with GLP-1 receptor agonists and can lead to dehydration if fluid intake is inadequate

Sleep problems at different tirzepatide dose levels Sleep disruption risk varies by dose, primarily because higher doses produce more aggressive appetite suppression and gastric slowing

Baxter RC (2023) Signaling pathways of the Insulin-like Growth Factor Binding Proteins

Now another drug called Mounjaro has been added to the race, and although it has not yet received FDA approval, but the approval process is underway

It is not licensed for the treatment of growth hormone deficiency in adults or children in the UK, and its use for weight management, anti-ageing, or performance enhancement is not supported by NICE guidelines