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Description
Dapagliflozin monotherapy in drug-nave patients with diabetes: A randomized-controlled trial of low-dose range
Furthermore, GLP-1 RA-mediated vasodilation can occur in states of low Nox-1/endothelin-1 and normal eNOS/guanylyl cyclase expression [117]
Results Compared with GLP-1 receptor agonists, the SGLT-2 inhibitor-GLP-1 receptor agonist combination was associated with a 30% lower risk of major adverse cardiovascular events (7.0 v 10.3 events per 1000 person years
(2025) 8:e2457349
Together, these two studies elucidate pathways that inform strategies coupling GLP-1R signaling to control of body weight in patients with diabetes or obesity
