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Some are easy to spot, and others happen behind the scenes

Based on current evidence, several practical recommendations can be outlined

Gels offer convenience and stable levels but require daily application and precautions to prevent transfer to others

Other common structural changes include aortic stenosis, myocardial fibrosis and myocyte stiffness

Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR, American Diabetes Association and European Association for the Study of Diabetes (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)