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Additionally, rapid changes in fluid and electrolyte balance during the first week of treatment may contribute to localized aches

The STEP 1 extension showed 11.6 percentage points of weight regained within 52 weeks of stopping semaglutide

Drugs that are actively secreted via cationic tubular secretion (e.g., amiloride) should be co-administered with caution with dofetilide since they could increase dofetilide plasma concentrations via potential competition for renal cationic secretion

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