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If you take blood thinners, supplements like fish oil or vitamin E, or high-dose aspirin, you may bruise more easily

Injection site reactions can occur with tirzepatide therapy, though they are generally mild to moderate in severity and tend to resolve spontaneously without intervention

SURMOUNT-5 was not included in the NMA as it was published after the SLR was conducted

The antibody-antigen interaction activates complement proteins and recruits additional immune cells, producing a reaction that is qualitatively different from the simple histamine-mediated response seen with initial injections

Retatrutide is an investigational triple hormone agonist (GLP-1, GIP, glucagon) showing promising early results for obesity and type 2 diabetes, while tirzepatide is an FDA-approved dual agonist (GLP-1, GIP) available for use today