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Therapeutic Scope and the Translational Mismatch Problem Clinically, GLP-1RAs are established therapies for obesity and type 2 diabetes (T2D), with expanding indications and ongoing investigation across multiple organ systems

Network meta-analysis of treatments for type 2 diabetes mellitus following failure with metformin plus sulfonylurea

Differentiating type 1 diabetes from type 2 diabetes Identifying whether an adult with newly diagnosed diabetes has type 1 diabetes may be challenging where the individual has features pointing towards both type 1 diabetes and type 2 diabetes, such as an older adult with a low or normal BMI or young adult with an elevated BMI

Note: If you are taking a GLP-1 medication and experience severe, localized abdominal pain that does not improve, do not assume it is just a side effect

Most gastroenterologists advise against GLP-1 medications for patients with moderate to severe gastroparesis