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189,190 In addition, the mitochondrial PGC-1 signaling pathway is also the mechanism of GLP-1 RA to protect neurons from tau hyperphosphorylation, indicating that mitochondrial dysregulation has crosstalk with tau pathology

A thorough medical evaluation is essential to determine if semaglutide or tirzepatide is right for you

Temporary dose reduction during tapering: Patients stepping down from higher maintenance doses may benefit from gradual exposure reduction rather than abrupt discontinuation

NNC0165-1875 has recently completed a phase 2 trial in combination with semaglutide 2.4 mg once weekly (NCT04969939), but results are not currently available

The Journal of Neuroscience, 34, 1530615318