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Anthems failure to produce any documentation to explain its rationale for excluding Zepbound for OSA under the terms of the Plan despite FDA approval for a non-weight loss use, and a physicians prescription suggests that no such documentation exists

They may be prescribed when commercially available products are unsuitable for an individuals medical needs, but have not been evaluated by the FDA to confirm safety or efficacy for any specific use

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Dedicated long-term trials investigating the benefits of such therapies on hospitalisation, major cardiovascular adverse events and all-cause mortality are required

According to the FDA prescribing information, the most common side effects are gastrointestinal in nature and include nausea (reported in approximately 24-29% of patients), diarrhea (18-23%), vomiting (8-15%), constipation (16-17%), and abdominal pain (10-11%)