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Rats were individually housed at 22 C on a reverse light:dark cycle (dark from 11:00 to 23:00 h), and provided with ad libitum access to 45% HFD (D12451, Research Diets, Inc., USA) and drinking water

[DOI] [PubMed] [Google Scholar] 66.Zhao H-J, Jiang X, Hu L-J, Yang L, Deng L-D, Wang Y-P, et al

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Pharmaceutical companies are now evaluating suppliers based on: Quality management systems Regulatory readiness Manufacturing consistency Risk management capabilities Global supply chain reliability As a result, suppliers operating under recognized standards such as ISO 13485 and ISO 15378 are becoming more attractive partners for pharmaceutical developers

Chemical modifications, such as amino acid mutations, addition of fatty acid chains, or design of synthetic analogs, can enhance their resistance to enzymatic degradation and significantly improve metabolic stability and half-life (Yu et al., 2018