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Prescription GLP-1 receptor agonists may be indicated for adults with type 2 diabetes not meeting glycemic targets, those with established cardiovascular disease or chronic kidney disease, or individuals with obesity and weight-related complications when lifestyle interventions prove insufficient

If phentermine works through one mechanism and GLP-1 medications work through another, would combining them produce additive or even synergistic weight loss

If phentermine works, and for some people it works very well, there is no reason to move to tirzepatide

Individual responses to nutrition, lifestyle changes, bariatric surgery, and GLP-1 therapies can vary

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 201640 for 195 countries and territories