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Q: What causes a weight-loss plateau, and how can the brains internal chemistry break past it

Some patients struggle with weight gain due to other conditions at play, like type 2 diabetes or hormonal disorders

Semaglutide Phase 3 trials showed approximately 15 to 17% weight loss, while retatrutide Phase 2 data showed up to 24.2%

In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin

Researchers reviewed data from nearly 2 million people treated by the Veterans Health Administration, including more than 216,000 patients prescribed GLP-1 medications