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But the arrival of GLP-1 (glucagon-like peptide-1) receptor agonists changed everything

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While drug-related clinical and laboratory adverse reactions were more frequent in the MK-677 group, mainly due to elevated blood glucose and glycated hemoglobin levels, none of these laboratory adverse reactions was severe [232]

This is because even though some small studies were done using these treatments, the research either had significant limitations or didnt show any true benefit for hot flash relief

Tirzepatide Side Effects | A-Z Guide Researchers have evaluated tirzepatide's safety and efficacy in various populations