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Separately, GLP-1 RA pretreatment in Abeta142-treated hippocampal primary cell cultures significantly increased phosphorylated CaMKII alpha -positive cells indicating that GLP-1 RAs may have neuroprotective effects through glutamate receptor-mediated responses.Reference Wang, Wang, Jiang, Yuan, Yu and Li 46 Taken together, GLP-1 RAs may have protective effects against neuropathological changes by promoting neurogenesis and synaptic plasticity

Finally, for the primary endpoint MACE, both SGLT-2 inhibitors and GLP-1RA are similar and both are superior to DPP-4 inhibitors

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