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Although GLP-1R expression is relatively low in many peripheral organs, GLP-1 medicines exert distinct antiinflammatory effects through both direct and indirect mechanisms that involve immune, vascular, and neural crosstalk (Figure 4)

42) In SUSTAIN-6, patients treated with semaglutide had a lower risk of developing or worsening nephropathy, but a higher risk of complications from diabetic retinopathy than those receiving placebo (40)

380 Firstly, the expression of GLP-1R is enhanced in the inflamed muscle fibers under pathological conditions, revealing the critical role of GLP-1R in regulating the muscles response to inflammation

GLP-1 receptor agonists take center stage, tickling the brain's appetite regulation center in the hypothalamus and leaving it giggling with delight

Dermatology 232(6):633639 Hogan AE et al (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus