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In addition, studies are investigating their broader benefits in patients with chronic kidney disease (CKD) and in elderly populations, with the aim of improving overall health outcomes in these high-risk groups Table 3

(Yes, liraglutide is also known as Victoza, but thats the formulation approved for diabetes management rather than weight loss Very much like the Ozempic and Wegovy story.) Saxenda, like a successful spin-off of a popular TV series, has been making waves since its FDA approval in 2014 for chronic weight management in adults with obesity or overweight and at least one weight-related comorbidity

Cell Metab 17: 819-837, 2013

Pharmacologic engagement of the GLP-1R is a proven strategy for treating hyperglycemia in diabetes and for reducing body weight

1,2 For this reason, its important to further understand the mechanism of GLP-1 therapies, said Lorenzo Leggio, a neuroendocrinologist at the National Institute on Drug Abuse who mediated the GLP-1 press conference at the 2025 Society for Neuroscience meeting