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Research suggests Akkermansia may influence GLP-1 secretion through improvements in gut barrier function and reduction of inflammation rather than directly stimulating GLP-1 production

The New England Comparative Effectiveness Public Advisory Council (CEPAC), a nationally recognized independent appraisal committee for ICER, found that adding tirzepatide to background therapy is superior to background therapy alone in a vote of 13 yes to 0 no

Safety, Suitability, and Practical Notes Common adverse effects: GI upset, nausea, constipation

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Lastly, sticking closely to the prescribed treatment schedule is crucial for maximizing effectiveness