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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, D'Alessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW

Novo Nordisk and Eli Lilly lead competition through strong clinical efficacy profiles and advanced injection device ecosystems

Chen Y, Li Y, Shen W, Li K, Yu L, Chen Q, et al

By mimicking the action of glucagon-like peptide-1, semaglutide plays a crucial role in appetite regulation and insulin secretion, leading to increased feelings of fullness and reduced caloric intake

Ice application before injection may provide comfort for some patients, though excessive cooling can cause vasoconstriction
