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( 10.1152/ajpendo.00418.2014) [DOI] [PubMed] [Google Scholar] Chepurny OG Matsoukas MT Liapakis G Leech CA Milliken BT Doyle RP & Holz GG

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The dose escalation schedule used in clinical trials followed a structured, gradual titration approach designed to improve tolerability and reduce gastrointestinal side effects