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A recent JAMA article showed that among people with T2DM, use of GLP-1 RAs was associated with a statistically significant decrease in dementia risk compared with other antidiabetic drugs

Some people did it the slow, hard way and seem to hold a grudge about there being an easier path, so a GLP-1 reads as cheating and muscle loss becomes the price you must be paying somewhere

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Increased Risk of Gallstones and Pancreatitis Patients taking GLP-1 medications are at higher risk of developing gallstones and gallbladder disease requiring surgery

Additionally, chronic treatment with GLP-1 RAs increases the abundance of anti-inflammatory microbial taxa (e.g., Bacteroidetes), which has been associated with improvements in both mood and glycemic control [94,95,99]