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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss

This research emphasizes their growing role in addressing obesity while shedding light on adherence challenges and long-term outcomes

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Orlistat is used as a weight loss drug, it is used in the treatment of losing weight for obesity, to maintain a steady weight and prevent weight gain.