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we did not observe phenotypes associated with lag-1 loss of function [11,17], including loss of glp-1 embryonic lethality or a smaller progenitor zone due to stem cells undergoing spatially premature meiotic entry, loss of lin-12 egg-laying/vulva defects, or loss of both lin-12 and glp-1 Lag larval arrest

Nausea is the most frequent side effect, typically emerging within hours to days of the first injection and often improving after 24 weeks as your body adjusts

6.1 MASLD and NASH Studies have shown that GLP-1RAs reduce hepatic fat content and improve liver histology in patients with MASLD, decreasing steatosis, ballooning necrosis, and liver enzyme levels

Signal Transduct Target Ther 9 (2024): 234

The results were promising: the triple agonists were more effective at reducing body weight and increasing energy expenditure compared to GLP-1 receptor mono-agonists and GLP-1 receptor/GIP receptor co-agonists