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Understanding whether these medications directly cause gallbladder problemsor whether rapid weight loss drives the associationis essential for patients and clinicians making treatment decisions

This section compares the most clinically relevant adverse events across every major option

10.1001/jama.2018.11406 [DOI] [PMC free article] [PubMed] [Google Scholar] Lanng, A

Inhibitors of the peptidomimetic class such as saxagliptin and vildagliptin mimic the dipeptide terminal of DPP4 at the cleavage site of the incretin hormone substrates

In practice, patients often report increased resilience to dietary indiscretions or brief interruptions in routinedemonstrating genuine metabolic adaptability