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Most patients find side effects manageable and far preferable to struggling with uncontrolled appetite

In October 2024, the FDA declared that tirzepatide was no longer in shortage, and shortly after in February 2025 announced the same for semaglutide

OXY-Reta (Retatrutide) 10 OXY-Reta () 10 ,

Diet Eating foods high in sodium may cause fluid retention

Some people may need to continue semaglutide long-term to maintain these gains, while others achieve lasting improvements that persist after treatment ends
