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Gordji-Nejad A, Matusch A, Kleedrfer S, et al

Soon after this, in 1907, MA Lane, at the University of Chicago, observed two sets of cells stained differently in the pancreatic islets which he called 'alpha' (A) and 'beta' (B) (Lane)

Substantial evidence supports that peptide-mediated GLP-1 secretion is a Ca 2+ sensitive process and involves L-cell signaling via the Ca 2+ sensing receptor (CaSR) and the peptide transporter 1 (PEPT1) [302]

241 Through this series of complex molecular and cellular mechanisms, GLP-1 plays a vital role in the physiological and pathological processes of metabolic diseases like T2DM