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At the end of the 28-day period, study subjects experienced significant weight loss (2.3 kg vs 0.5 kg) compared to saline treated controls in addition to concurrent changes in leptin and adiponectin suggesting reduction in adiposity (32)

[DOI] [PubMed] [Google Scholar] 16.Sivalingam S, Wasehuus VS, RotbainCurovic V, et al

1,2 Separate dedicated trials are the right venue for testing neuroprotection claims

The former is currently awaiting FDA approval for a handful of oral, daily GLP-1 agonists, while the latter is developing combination therapies that use their muscle-preserving antibodies, trevogrumab and garetosmab, alongside GLP-1 drugs like Wegovy and Ozempic, to improve fat loss while preserving muscle mass

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