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The nervous system has fundamentally misinterpreted a harmless signal as dangerous, and the brain responds with genuine pain
237 The therapeutic effects of the amino salicylic acid class drug sulfalazine, 238 the antibiotics azithromycin and buspirone, 239 the opioid agonist human opiorphin, 240 the PDE5 inhibitor sildenafil 241 and many other commonly used clinical drugs in UC are attributed to the inhibition of the NFB pathway, which inhibits the expression of inflammatory cytokines and the infiltration of inflammatory cells, alleviating intestinal epithelial damage
The risk is that the potency and the chemical physical properties of the drug are altered 7
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Wang D, Day EA, Townsend LK, Djordjevic D, Jrgensen SB, Steinberg GR
